In rural areas of resource-poor countries, basic access to health workers, medicines, and supplies is often stalled by the poor condition of health transportation. Social enterprise Riders for Health strengthens African health supply chains by providing reliable vehicle management and training on preventive maintenance. The Value Chain Innovation Initiative conducted a field trial in Zambia which found that Riders for Health services resulted in increased health worker trips to villages, the number of patients seen, and geographical health reach. This study highlights the importance of reliable transportation as an essential component of health systems.