This paper considers how research in operations management can support the development of strategies for the design and management of global supply chains. It includes a model-based statement of the problem and an overview of highlights of past research that is relevant to both theory and practice. The paper identifies opportunities for research that focus on how global supply chain modeling can inform the current debate concerning the reaction of firms to changes in government policy that are relevant to global manufacturing and logistics. This includes policy changes, such as tariffs, content requirements, taxes, and investment incentives.